eClamp(دستگاه ثبت patch clamp)

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درباره eClamp

 

eClamp intracellular and patch clamp recording System

 pc-p3
 hero title

 

eClamp is the best solution ever for intracellular and pach calmp recording

eCalmp is an all-in-one system incluing amplifier and clamp stimulator , analog to digital converter, separated  curent  stimulator , electrode impedance meter

You can  Design The best possible  stimulus protocol  by a digital pulse generator. 
مشخصات اصلی eClamp

 eClamp is the best  solution ever for   intracellular

and patch clamp recording  

  • Single electrode voltage and current clamp
  • Patch clamping
  • Single channel recording
  • Whole cell recording
  • Low noise
  • Software user interface
  • USB bus powerd design
  • High resolution analog to digital converter
  • Low weight and easy to use
  • Plug and Play (USB2 connector)
  • Operating voltage: 5V DC
  • Dimensions (w x h x d): 120 x 60 x 28 mm
  • Net weight 200g

 pc-p3

مشخصات فنی eClamp

Data acquisition 
Processor32 bit ,168MHz
FIFO Memory64KB
Data transferUSB2

break

Analog to digital converterChannel numners1 Channel
ADC resolution24bit
Linearity error±7.6ppm (maximum)
Sample rate100Ks/s per channel
Analog input range±2.5v
InterfaceSerial

Isolation type

Optical
Isolation voltage2500V
Isolation resistance10 12Ω

break

Electrical  stimulatorModeConstant current, Unipolar, Isolated
Number of channels1 Channels
Current range0 to 4mA  or  0 to 20mA (optional)
Current resolution1µA or 5µA (optional)
Output waveformDC or current pulse
current controlYes, software controll by 12 bit DAC
Current amplitude error3LSB (maximum)
Polarity inversionYes, software controll by Relay
Output switchYes, software controll by Relay
Output voltage compliance150V
Current rise time and delay5μs, typical (1KΩ load)
Current fall time and delay5μs, typical (1KΩ load)
Isolation typeOptical
Isolation voltage2500V
Isolation resistance10 12Ω

break

Microelectrode Amplifier
Amplifier TypeIsolated, Intracellular
Number of channels1 Channels
Gain20
Input voltage range±2.5V
Maximum analog input voltage±2.5V
Input impedance10 12Ω, common mode and differential
Input leakage current60pA (typical)
Input capacitance8pF
Common mode rejection ratio75dB @ 50/60Hz
Isolation typeOptical
Isolation voltage2500V
Isolation resistance10 12Ω
High cut filter500, 1000,3000,5000, 10000Hz
break
 Pulse generator      Experiment protocols Single trial, Multi trial , Single protocol, Multi-protocol
 Stimulation Timing pattern 4
 Pattern parameters Delay, Pulse duration, Pulse cycle, Pulse Numbers, Trial period, Trial Number
 Timing pattern resolution 10us
 Mixers 2ch Internal stimulator, 2ch Mechanical stimulator , 2ch Digital outs,
 Mixer Inputs Pattern1, Pattern2, Pattern3, Pattern4, Digital Input1, Digital Input2
   

 

 

break

Voltage Clamp

Selectable pulse amplitude
0 to ±1V
Selectable pulse duration0.1 to 500ms
Selectable Seal test frequency2 to 1000Hz
Recording Current range0.2 pA to 200nA
Capacitance compensationManual / Auto
Series resisance compensationManual / Auto
 
break
 Voltage Clamp   Selectable pulse amplitude 2nA to 200nA
Selectable pulse duration 0.1 to 500ms
Pipette Capacitance neutralization Manual / Auto
Tuning frequency 2 to 1000Hz
Output offset-trimming Auto
   
break

 Requirements

CPU : 2core,  2Ghz, 
memory : 2GB
Graphic : 1024,768
Audio : Internal or external sound card

PC
Operating SystemWindows 7
SoftwareDotnet Framework 4 or higher
نرم افزار

eProbe All you need to analysis neuro-electrophysiology signals

All

 

 

 Field potential signal analysis

 

Import data from previous version (NeuroTrace)
Display signal on high performance offline scope
Ability to optimize scope scales, both vertical and horizontal
Signal visualization in single and multi-trial mode
Signal inverting
Trial trimming (Disable bad trial) 
Hyper polarization, EPSP, PS, VP. 
One and multi trial Analysis 
Four LFP analysis mode (Standard, EPSP, Volley Potential (VP) + EPSP, PS mode)
Automatic measurement of defined variables (max, min, slope of the all analysis  line, 90%-10% of the line slope, area under the curve, start time, delay and response end) 
Saving data analysis as a binary or excel file/ image/ analysis template
Potentalize EPSP

 

Single-unit signals (spike) analysis

 

PSTH hand             

 

           

               PSTH Analysis

 

 

                - Show sorted action potential in window discriminator

  

                - Show 8 channel  PSTH

 

                - Audio monitoring of raw signal and spikes  

 

                - Measurement of delayed and frequency response, max, min, average,

 

                  standard deviation and neuronal responses

 

                - Analysis for spinal cord neurons

 

                - Saving data analysis as a binary or excel file/ image/ analysis template

 

                

 

 

 

EEG signal analysis


 

 

Spike count

 

Calculating of spike number
Saving data analysis as binary or excel file/ image/ analysis template

SpikeCount

 

 break 

 

FFT         

Frequency analysis

 

Caclculate power and phase frequency range 0-100 HZ, between two custome time
Drowing power and phase frequency graph
Saving data analysis as binary or excel file/ image

break

 

Statistical analysis

 

PSTH statis

 

 

 

eProbe a potent software for neuro-electrophysiology data analysis!

 

 

PSTH hand 

 

 

Potent software for electrophysiological data analysis.

Data extraction from EEG, field potential and single-unit signals (PSTH analysis and offline sorting) and statistical analysis of acquired data.

PSTH analysis and real time demonstration of recorded signals in single-unit data analysis mode with offline sorting and analysis capabilities.

Making data banks from results in excel or word files format.

Online demonstration of raw signal.

Offline PSTH analysis output includes average firing rate of neuron, standard deviation of firing, latency time of response, minimum and                           maximum response and spike count of different types of nerve fibers.

Special modes for analyzing Uni-trial and multi-trial experiments.

Analysis Field potential, volley potential, EPSP and PS signals in single-pulse or paired-pulse recording mode.

EPSP analysis including baseline resetting, measuring slope, amplitude, area under curve, latency time and minimum and maximum response.

EEG analysis including spike count, average of spikes amplitude, phase and power spectrum.

Graphical output for using in scientific manuscripts.

User friendly installation and application. 

Complete manual for installation, application and analysis.

 


Some publications dealing with eProbe

Effects of apomorphine and β-carbolines on firing rate of neurons in the ventral pallidum in the rats; 
Behavioural Brain Research, Volume 227, Issue 1, 1 February 2012, Pages 109-115
Formalin-Induced Differential Activation of Nucleus Cuneiformis Neurons in the Rat: An Electrophysiological Study; The Journal of Pain, Volume 11, Issue 1, January 2010, Pages 32-43
Single whisker experience started on postnatal days 0, 5 or 8 changes temporal characteristics of response integration in layers IV and V of rat barrel cortex neurons;
Brain Research Bulletin, Volume 74, Issues 1–3, 14 September 2007, Pages 29-36
Dorsal raphe nucleus stimulation modulates the response of layers IV and V barrel cortical neurons in rat; Brain Research Bulletin, Volume 68, Issue 6, 15 February 2006, Pages 430-435
Electrical stimulation of locus coeruleus strengthens the surround inhibition in layer V barrel cortex in rat; Neuroscience Letters, Volume 401, Issue 3, 3 July 2006, Pages 280-284
مقایسه محصولات حیوان

 

محصول

 

 

electromodule

 

eLab2/4/8/16/32

 

eClamp

 

تعداد کانال آمپلی فایر

 

1

8/16/32

1

 

نوع آمپلی فایر

 

تفاضلی/مستقیم

تفاضلی/مستقیم

مستقیم

 

دقت مبدل آنالوگ به دیجیتال

 

24 bit

24 bit

24 bit

 

نرخ نمونه برداری هرکانال

 

50ks/s

30-50ks/s

100ks/s

 

پردازش گر

 

FPGA

32bit/168MHZ

32bit/168

MHZ

 

نوع اتصال

 

USB2

USB2

USB2

 

محرک جریان

 

دارد

4/20mA,150V))

دارد

( 4/20mA,150V)

دارد

( 4/20mA,150v)

 

بهره

 

20

50

1

 

ورودی دیجیتال

 

2

2

2

 

خروجی دیجیتال

 

2

2

2

 

ورودی آنالوگ

 

0

0

0

 

خروجی آنالوگ

 

0

0

0

 

ابعاد(طول/عرض/ارتفاع)mm

 

366x116x350

120x28x60

120x28x60

       

        مقاومت ورودی

 

1012 Ω

1012 Ω

1012 Ω 

 

کارکردباتری قابل شارژ

 

5V adaptor–no Bat

5V  USB input –no Bat

5V  USB input –no Bat

 

پهنای باند فیلتر

0.5Hz -3KHz

0.5Hz -10KHz

DC -10KHz

کاربرددرثبت الکتروانسفالوگرام/

الکتروکورتیکوگرام/

الکتروکاردیوگرافی/

الکترومیوگرافی

الکترواکولوگرافی

دارد

دارد

ندارد

کاربرددرثبت پتانسیل

وابسته به رخداد(ERP)

ندارد

دارد

ندارد

سنسور مقاومت پوست،دما،فشارخون حجمی،

EEG,EMG,ECG

ندارد

ندارد

ندارد

 

ثبت پتانسیل میدانی(LFP)

دارد

دارد

ندارد

 

ثبت تک واحدی(SUR)

 

دارد

دارد

ندارد

ثبت داخل سلولی

Patch Clamp (Voltage /Current

ندارد

ندارد

دارد

 

 ثبت سرعت هدایت عصبی(NCV)

دارد

دارد

ندارد

 

کیندلینگ

 

دارد

دارد

ندارد

 

پتانسیل برانگیخته بینایی

 

ندارد

دارد

ندارد

 

دسته بندی اسپایک ها

 

Offline

Offline/Online

ندارد

 

eClamp intracellular and patch clamp recording System

 pc-p3
 hero title

 

eClamp is the best solution ever for intracellular and pach calmp recording

eCalmp is an all-in-one system incluing amplifier and clamp stimulator , analog to digital converter, separated  curent  stimulator , electrode impedance meter

You can  Design The best possible  stimulus protocol  by a digital pulse generator. 

 eClamp is the best  solution ever for   intracellular

and patch clamp recording  

 pc-p3

Data acquisition 
Processor32 bit ,168MHz
FIFO Memory64KB
Data transferUSB2

break

Analog to digital converterChannel numners1 Channel
ADC resolution24bit
Linearity error±7.6ppm (maximum)
Sample rate100Ks/s per channel
Analog input range±2.5v
InterfaceSerial

Isolation type

Optical
Isolation voltage2500V
Isolation resistance10 12Ω

break

Electrical  stimulatorModeConstant current, Unipolar, Isolated
Number of channels1 Channels
Current range0 to 4mA  or  0 to 20mA (optional)
Current resolution1µA or 5µA (optional)
Output waveformDC or current pulse
current controlYes, software controll by 12 bit DAC
Current amplitude error3LSB (maximum)
Polarity inversionYes, software controll by Relay
Output switchYes, software controll by Relay
Output voltage compliance150V
Current rise time and delay5μs, typical (1KΩ load)
Current fall time and delay5μs, typical (1KΩ load)
Isolation typeOptical
Isolation voltage2500V
Isolation resistance10 12Ω

break

Microelectrode Amplifier
Amplifier TypeIsolated, Intracellular
Number of channels1 Channels
Gain20
Input voltage range±2.5V
Maximum analog input voltage±2.5V
Input impedance10 12Ω, common mode and differential
Input leakage current60pA (typical)
Input capacitance8pF
Common mode rejection ratio75dB @ 50/60Hz
Isolation typeOptical
Isolation voltage2500V
Isolation resistance10 12Ω
High cut filter500, 1000,3000,5000, 10000Hz
break
 Pulse generator      Experiment protocols Single trial, Multi trial , Single protocol, Multi-protocol
 Stimulation Timing pattern 4
 Pattern parameters Delay, Pulse duration, Pulse cycle, Pulse Numbers, Trial period, Trial Number
 Timing pattern resolution 10us
 Mixers 2ch Internal stimulator, 2ch Mechanical stimulator , 2ch Digital outs,
 Mixer Inputs Pattern1, Pattern2, Pattern3, Pattern4, Digital Input1, Digital Input2
   

 

 

break

Voltage Clamp

Selectable pulse amplitude
0 to ±1V
Selectable pulse duration0.1 to 500ms
Selectable Seal test frequency2 to 1000Hz
Recording Current range0.2 pA to 200nA
Capacitance compensationManual / Auto
Series resisance compensationManual / Auto
 
break
 Voltage Clamp   Selectable pulse amplitude 2nA to 200nA
Selectable pulse duration 0.1 to 500ms
Pipette Capacitance neutralization Manual / Auto
Tuning frequency 2 to 1000Hz
Output offset-trimming Auto
   
break

 Requirements

CPU : 2core,  2Ghz, 
memory : 2GB
Graphic : 1024,768
Audio : Internal or external sound card

PC
Operating SystemWindows 7
SoftwareDotnet Framework 4 or higher

eProbe All you need to analysis neuro-electrophysiology signals

All

 

 

 Field potential signal analysis

 

Import data from previous version (NeuroTrace)
Display signal on high performance offline scope
Ability to optimize scope scales, both vertical and horizontal
Signal visualization in single and multi-trial mode
Signal inverting
Trial trimming (Disable bad trial) 
Hyper polarization, EPSP, PS, VP. 
One and multi trial Analysis 
Four LFP analysis mode (Standard, EPSP, Volley Potential (VP) + EPSP, PS mode)
Automatic measurement of defined variables (max, min, slope of the all analysis  line, 90%-10% of the line slope, area under the curve, start time, delay and response end) 
Saving data analysis as a binary or excel file/ image/ analysis template
Potentalize EPSP

 

Single-unit signals (spike) analysis

 

PSTH hand             

 

           

               PSTH Analysis

 

 

                - Show sorted action potential in window discriminator

  

                - Show 8 channel  PSTH

 

                - Audio monitoring of raw signal and spikes  

 

                - Measurement of delayed and frequency response, max, min, average,

 

                  standard deviation and neuronal responses

 

                - Analysis for spinal cord neurons

 

                - Saving data analysis as a binary or excel file/ image/ analysis template

 

                

 

 

 

EEG signal analysis


 

 

Spike count

 

Calculating of spike number
Saving data analysis as binary or excel file/ image/ analysis template

SpikeCount

 

 break 

 

FFT         

Frequency analysis

 

Caclculate power and phase frequency range 0-100 HZ, between two custome time
Drowing power and phase frequency graph
Saving data analysis as binary or excel file/ image

break

 

Statistical analysis

 

PSTH statis

 

 

 

eProbe a potent software for neuro-electrophysiology data analysis!

 

 

PSTH hand 

 

 

Potent software for electrophysiological data analysis.

Data extraction from EEG, field potential and single-unit signals (PSTH analysis and offline sorting) and statistical analysis of acquired data.

PSTH analysis and real time demonstration of recorded signals in single-unit data analysis mode with offline sorting and analysis capabilities.

Making data banks from results in excel or word files format.

Online demonstration of raw signal.

Offline PSTH analysis output includes average firing rate of neuron, standard deviation of firing, latency time of response, minimum and                           maximum response and spike count of different types of nerve fibers.

Special modes for analyzing Uni-trial and multi-trial experiments.

Analysis Field potential, volley potential, EPSP and PS signals in single-pulse or paired-pulse recording mode.

EPSP analysis including baseline resetting, measuring slope, amplitude, area under curve, latency time and minimum and maximum response.

EEG analysis including spike count, average of spikes amplitude, phase and power spectrum.

Graphical output for using in scientific manuscripts.

User friendly installation and application. 

Complete manual for installation, application and analysis.

 


Some publications dealing with eProbe

Effects of apomorphine and β-carbolines on firing rate of neurons in the ventral pallidum in the rats; 
Behavioural Brain Research, Volume 227, Issue 1, 1 February 2012, Pages 109-115
Formalin-Induced Differential Activation of Nucleus Cuneiformis Neurons in the Rat: An Electrophysiological Study; The Journal of Pain, Volume 11, Issue 1, January 2010, Pages 32-43
Single whisker experience started on postnatal days 0, 5 or 8 changes temporal characteristics of response integration in layers IV and V of rat barrel cortex neurons;
Brain Research Bulletin, Volume 74, Issues 1–3, 14 September 2007, Pages 29-36
Dorsal raphe nucleus stimulation modulates the response of layers IV and V barrel cortical neurons in rat; Brain Research Bulletin, Volume 68, Issue 6, 15 February 2006, Pages 430-435
Electrical stimulation of locus coeruleus strengthens the surround inhibition in layer V barrel cortex in rat; Neuroscience Letters, Volume 401, Issue 3, 3 July 2006, Pages 280-284

 

محصول

 

 

electromodule

 

eLab2/4/8/16/32

 

eClamp

 

تعداد کانال آمپلی فایر

 

1

8/16/32

1

 

نوع آمپلی فایر

 

تفاضلی/مستقیم

تفاضلی/مستقیم

مستقیم

 

دقت مبدل آنالوگ به دیجیتال

 

24 bit

24 bit

24 bit

 

نرخ نمونه برداری هرکانال

 

50ks/s

30-50ks/s

100ks/s

 

پردازش گر

 

FPGA

32bit/168MHZ

32bit/168

MHZ

 

نوع اتصال

 

USB2

USB2

USB2

 

محرک جریان

 

دارد

4/20mA,150V))

دارد

( 4/20mA,150V)

دارد

( 4/20mA,150v)

 

بهره

 

20

50

1

 

ورودی دیجیتال

 

2

2

2

 

خروجی دیجیتال

 

2

2

2

 

ورودی آنالوگ

 

0

0

0

 

خروجی آنالوگ

 

0

0

0

 

ابعاد(طول/عرض/ارتفاع)mm

 

366x116x350

120x28x60

120x28x60

       

        مقاومت ورودی

 

1012 Ω

1012 Ω

1012 Ω 

 

کارکردباتری قابل شارژ

 

5V adaptor–no Bat

5V  USB input –no Bat

5V  USB input –no Bat

 

پهنای باند فیلتر

0.5Hz -3KHz

0.5Hz -10KHz

DC -10KHz

کاربرددرثبت الکتروانسفالوگرام/

الکتروکورتیکوگرام/

الکتروکاردیوگرافی/

الکترومیوگرافی

الکترواکولوگرافی

دارد

دارد

ندارد

کاربرددرثبت پتانسیل

وابسته به رخداد(ERP)

ندارد

دارد

ندارد

سنسور مقاومت پوست،دما،فشارخون حجمی،

EEG,EMG,ECG

ندارد

ندارد

ندارد

 

ثبت پتانسیل میدانی(LFP)

دارد

دارد

ندارد

 

ثبت تک واحدی(SUR)

 

دارد

دارد

ندارد

ثبت داخل سلولی

Patch Clamp (Voltage /Current

ندارد

ندارد

دارد

 

 ثبت سرعت هدایت عصبی(NCV)

دارد

دارد

ندارد

 

کیندلینگ

 

دارد

دارد

ندارد

 

پتانسیل برانگیخته بینایی

 

ندارد

دارد

ندارد

 

دسته بندی اسپایک ها

 

Offline

Offline/Online

ندارد

بالا